The Karl Z. Morgan Papers house a variety of materials documenting Dr. Morgan's tenure at Oak Ridge National Laboratory and at the Georgia Institute of Technology. The collection consists primarily of documents and reports but also houses a number of road maps and travel brochures, a Monnaie de Paris Eisenhower commemorative coin, and an American bicentennial commemorative bag.

The collection also includes a report entitled The Exposure of the Population-at-Large to Ionizing Radiation that Morgan compiled in 1960 for the Oak Ridge National Laboratory as well as an undated report on the effects of radiation on the human body. The collection also houses such materials as forms, documents, and memoranda from both Oak Ridge National Laboratory and Georgia Tech, job postings compiled by the American Association of Physics in Medicine, and a collection of Morgan's contacts.

Morgan's other papers contain a handwritten note indicating that Karen Silkwood's lawyer would be calling him. Morgan testified on behalf of Karen Silkwood, a laboratory technician who reported health and safety violations at the Kerr-McGee Corporation before being killed in a car crash as she was on the way to meet with a reporter from The New York Times about her accusations.